Eyelash serums are a popular choice for those seeking longer, fuller, and healthier lashes without the commitment of lash extensions or the potential side effects of prostaglandin-based formulas.
Ideal for sensitive eyes or those preferring cruelty-free, natural formulas, these serums harness peptides, biotin, and plant extracts to promote healthy lash growth.
This guide answers your top questions about choosing, using, and maximising results from these serums, helping you achieve voluminous lashes without the risks of prostaglandins.
Table of content
Key Takeaways
- Prostaglandin-free eyelash serums promote lash growth using safer ingredients like peptides, amino acids, and plant extracts.
- Look for ophthalmologist-tested formulas to ensure safety for sensitive eyes or contact lens wearers.
- Consistent daily use (typically 4–12 weeks) is crucial for visible results in lash length and fullness.
- Cruelty-free and gentle formulas with ingredients like hyaluronic acid or vitamin C are ideal for minimising irritation.
- Always perform a patch test to avoid potential allergic reactions, especially for sensitive skin.
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Why Choose Prostaglandin-Free Serums?
Prostaglandin analogues, commonly found in some lash serums, are synthetic compounds that mimic hormones to stimulate hair growth. While effective, they can cause side effects like eye irritation, skin darkening, or even fat loss around the eyes with long-term use.
The MHRA (Medicines and Healthcare products Regulatory Agency) advises caution with such ingredients in over-the-counter cosmetics due to potential risks.
Prostaglandin-free serums rely on alternative ingredients like peptides, biotin, or serenoa serrulata fruit extract to nourish eyelash hair follicles and support the lash growth cycle without these risks. Eye doctors often recommend serums without prostaglandins for individuals concerned about side effects or with sensitive eyes.
These serums are ideal for those with sensitive eyes or who prefer a gentler, natural approach to achieving longer, fuller lashes. Users frequently report positive results with these alternatives, noting improvements in lash length and fullness.
In the UK, where access to dermatological advice is readily available through the NHS, it's wise to discuss any concerns with a GP if you experience persistent irritation.
Key Ingredients to Look For
Effective prostaglandin-free serums often contain:
- Peptides: Stimulate lash growth by strengthening hair follicles.
- Hyaluronic Acid/Sodium Hyaluronate: Hydrates lashes to prevent breakage and promote a healthy lash line.
- Biotin: Supports keratin production for stronger, thicker lashes.
- Plant Extracts (e.g., swertia japonica or ginseng): Nourish follicles and enhance lash health.
- Vitamin C: Protects lashes from environmental damage and supports collagen production.
Just as with hair care routines, choosing serums with safe, high-quality ingredients is essential for maintaining healthy lashes.
Look for serums labelled as cruelty-free, ophthalmologist-tested, and suitable for contact lens wearers to ensure safety and efficacy.
How Do Prostaglandin-Free Serums Work for Lash Growth?
Prostaglandin-free serums nourish eyelash follicles with peptides, vitamins, and plant extracts to extend the anagen (growth) phase of the lash cycle, resulting in longer, fuller lashes within 4–12 weeks of consistent use. A lash growth serum is specifically formulated to help users achieve longer looking lashes by nourishing and strengthening the follicles.
Understanding the Lash Growth Cycle
The eyelash growth cycle consists of three phases: anagen (growth), catagen (transition), and telogen (resting). Prostaglandin-free serums work by:
- Extending the anagen phase to promote longer lashes.
- Strengthening hair follicles to prevent breakage and sparse lashes.
- Hydrating the lash line with ingredients like hyaluronic acid to support healthy lashes.
Unlike prostaglandin-based serums, these formulas avoid hormonal manipulation, reducing the risk of irritation or skin darkening while still delivering visible results.
Application Tips for Best Results
To maximise effectiveness:
- Apply a thin line of serum along the upper lash line (and lower lashes if directed) once or twice daily.
- Use on clean, makeup-free lashes to ensure proper absorption.
- Avoid getting serum in the eyes to prevent irritation.
- Perform a patch test on a small area of skin to check for sensitivity before full use.
- Consistent daily application is key, with most users seeing noticeable results in 4–8 weeks and optimal results after 12 weeks.
What Are the Best Eyelash Serums Available Without Prostaglandin?
The following options are considered the best eyelash growth serums available without prostaglandin. Compared to other lash serums, these products are recognised for their superior safety and effectiveness, offering impressive results in lash length, strength, and health without the potential side effects often associated with other lash serums.
#1 Best Overall: Scandinavian Biolabs Eyelash Growth Serum – A highly effective, plant-based formula known for its natural lash-enhancing properties.
- Best for Sensitive Eyes: RevitaLash Cosmetics Advanced Eyelash Conditioner – Dermatologist-approved and gentle on sensitive eyes while delivering visible results.
- Best Budget-Friendly: Maybelline Boosting Eyelash Serum – An affordable option that effectively promotes lash growth without breaking the bank.
- Best Luxury Pick: Lancôme Lash Revitalizing Serum – A premium serum that revitalizes and strengthens lashes for a more youthful appearance.
- Best for Natural Ingredients: The Ordinary Lash and Brow Serum – A simple, effective serum using natural peptides to promote lash health.
- Best for Fuller Lashes: Vegamour Lash Serum – Vegan, cruelty-free, and designed to give you thicker, fuller lashes naturally.
- Best for Fast Results: Obagi Eyelash Enhancing Serum – Known for delivering quick, noticeable improvements in lash length and volume.
Scandinavian Biolabs Eyelash Growth Serum
Scandinavian Biolabs Eyelash Growth Serum leverages the Bio-Pilixin® formula to promote fuller-looking lashes by nourishing and protecting lash follicles.
Featuring Capilia Longa for visible lash density improvement, biotin for hydration and breakage prevention, and an amino-acid blend to enhance lash strength, this serum offers results in 4–6 weeks.
Dermatologically tested and crafted in Denmark, it’s a safe and effective choice for those seeking natural lash enhancement.
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2. RevitaLash Cosmetics Advanced Eyelash Conditioner
The RevitaLash Advanced Eyelash Conditioner stands out among the best eyelash growth serums, impressing users with noticeable results.
After just a month of application, many report a noticeable improvement in lash length, often prompting questions about professional lash treatments.
Its ease of use is another plus, with a fine brush tip that ensures precise application without excess product or discomfort.
It's highlighted for containing less prostaglandin, minimising potential side effects while delivering fuller, shinier lashes thanks to its peptide-rich formula.
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3. Maybelline Boosting Eyelash Serum
The Maybelline Boosting Eyelash Serum stands out as the best budget-friendly option for those new to eyelash serums or looking for an effortless application. Its mascara-like bristled wand makes application intuitive, mirroring the familiar action of applying mascara.
This serum enhances lash volume and promotes thicker, healthier lashes over time, thanks to its blend of arginine and pro-vitamin B5.
After ten weeks of consistent use, a significant improvement in lash volume and health was noticeable, making it an excellent choice for those seeking effective results without a hefty price tag.
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4. Lancôme Lash Revitalizing Serum
For those with sensitive eyes or skin conditions like eczema, the Lancôme Cils Booster Lash Revitalizing Serum offers a gentle yet potent formula.
It's designed to be irritation-free, integrating seamlessly into nightly skincare routines without causing discomfort or adverse reactions.
This serum's fast-drying, fragrance-free formula ensures a hassle-free application, requiring just a single dip for both eyes.
Users have reported noticeable enhancements in lash length and thickness, with a significant reduction in lash loss, making it a top contender for both effectiveness and sensitivity considerations.
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5. The Ordinary Lash and Brow Serum
The Ordinary Lash and Brow Serum is a highly sought-after option for those looking to enhance their lashes and brows without the harsh effects of prostaglandins. Its affordability and gentle formula make it a favourite among shoppers.
Featuring key ingredients like panthenol, biotinoyl tripeptide-1, acetyl tetrapeptide-3, and trifolium pratense flower extract, it aims to increase both density and thickness of lashes and brows.
While the necessity for twice-daily application might seem demanding, the fast-drying nature of the serum and the promise of visible results in just four weeks make it a compelling choice for those committed to their beauty routines.
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6. Vegamour Lash Serum
Vegamour's GRO+ Advanced Lash Serum is distinguished by its inclusion of broad-spectrum CBD, mung bean, and red clover, components that contribute to a healthier lash line and foster natural lash growth.
Its vegan and cruelty-free credentials, coupled with a formula that's gentle on sensitive eye areas, make it a standout for those seeking ethical beauty solutions.
Although it's not renowned for instant, dramatic outcomes, this lash-enhancing serum promises gradual, natural enhancement, especially noticeable in the inner lashes after consistent use over a month.
For those prioritising a gentle and sustainable method to achieve long lashes, Vegamour presents an appealing option, though patience is necessary for visible improvements.
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7. Obagi Eyelash Enhancing Serum
The Obagi Nu-Cil Eyelash Enhancing Serum offers a premium lash growth solution, utilising the brand's proprietary NouriPlex Technology for significant lash enhancement.
This technology blends panthenol, biotin, sodium hyaluronate, and a unique lipid compound to effectively enhance lash growth.
Despite its popularity, users should note its inclusion of dehydrolatanoprost, a prostaglandin-based lash serum ingredient, raising concerns similar to prescription options like Latisse.
Obagi's transparent warning about the possibility of permanent iris pigmentation changes and potential eyelid darkening, is crucial to consider for anyone weighing the benefits against the risks of using such a potent formula.
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Are Prostaglandin-Free Serums Safe for Sensitive Eyes?
Yes, prostaglandin-free serums are generally safe for sensitive eyes, especially those labelled ophthalmologist-tested or formulated for contact lens wearers, but always perform a patch test to confirm compatibility.
If you have any concerns about using a new eyelash serum, consult an optician or GP for personalised advice and to ensure the product is safe for your eyes.
Safety Considerations for Sensitive Skin and Eyes
Prostaglandin-free serums are designed to be gentler than their prostaglandin-containing counterparts, making them suitable for sensitive skin and eyes. Key safety features include:
- Ophthalmologist-Tested Formulas: Ensure compatibility with the delicate eye area.
- Gentle Ingredients: Ingredients like caprylyl glycol or phytic acid act as preservatives and antioxidants without causing irritation.
- No Prostaglandins: Eliminates risks like eye redness, itching, or skin darkening.
However, individuals with a history of eye irritation or allergies should consult an eye doctor before use and monitor for any discomfort during initial applications.
Choosing the Right Serum for Sensitive Eyes
Look for serums with:
- Minimal fragrance to reduce irritation risk.
- Hydrating ingredients like sodium hyaluronate to soothe dry skin around the lash line.
- Clear labelling indicating suitability for sensitive eyes or contact lens wearers.
Popular options like The Ordinary Multi-Peptide Lash and Brow Serum and Vegamour Gro Lash Serum are formulated with these considerations, offering gentle yet effective solutions.
Can Prostaglandin-Free Serums Replace Lash Extensions or Mascara?
Prostaglandin-free serums can enhance natural lashes to reduce reliance on eyelash extensions or mascara, but they don’t provide the instant dramatic effect of these alternatives.
Choosing a lash serum without prostaglandins offers a safer, long-term alternative to eyelash extensions, promoting natural lash health with consistent use.
Comparing Serums to Lash Extensions and Mascara
- Lash Extensions: Provide instant length and volume but require maintenance and can damage natural lashes. Serums strengthen natural lashes over time, offering a low-maintenance alternative.
- Mascara: Temporarily enhances lash appearance but doesn’t improve lash health. Serums nourish follicles for long-term improvements in lash length and fullness.
- False Lashes: Offer a quick fix for voluminous eyelashes but can be cumbersome. Serums provide a natural, lasting solution without daily application.
Prostaglandin-free serums are ideal for those seeking a sustainable way to achieve longer, healthier lashes without the upkeep of extensions or daily makeup.
Combining Serums with Other Lash Products
For best results:
- Use serums consistently to enhance natural lashes, reducing the need for mascara or extensions.
- Apply serum before mascara to avoid interference with absorption.
- Avoid combining with prostaglandin-based serums to prevent potential risks like irritation.
- With regular use, serums can help achieve a natural look that rivals the effect of false lashes or extensions.
What Are the Long-Term Benefits of Prostaglandin-Free Serums?
Long-term use of prostaglandin-free serums can lead to stronger, longer, and fuller lashes, improved lash health, and reduced breakage, with results maintained through consistent daily application.
Long-Term Effects on Lash Health
Unlike prostaglandin-based serums, which may cause side effects with prolonged use, prostaglandin-free serums offer:
- Strengthened Lashes: Ingredients like biotin and amino acids reinforce lash structure.
- Improved Follicle Health: Plant stem cells and extracts like serenoa serrulata nourish follicles for sustained growth.
- Reduced Breakage: Hydrating ingredients prevent brittle, sparse lashes.
- No Skin Darkening or Fat Loss: Avoids long-term risks associated with prostaglandins.
With consistent use, users can expect visible improvements in lash length and density, often noticeable within a few weeks and optimal after 3–6 months.
Maintaining Results
To sustain results:
- Continue daily application as directed, even after achieving desired results.
- Store serums properly (cool, dry place) to maintain efficacy.
- Monitor for any changes in lash health and consult an eye doctor if irritation occurs.
Regular use ensures lashes remain voluminous and healthy, offering a natural alternative to lash-enhancing makeup or extensions.
FAQ
Can prostaglandin-free serums be used during pregnancy?
It’s best to consult a healthcare provider before using any lash serum while pregnant or breastfeeding. Prostaglandin-free formulas are generally considered safer than those containing hormone-like ingredients, but individual sensitivities and potential allergies still matter. A doctor or midwife can review the ingredient list and ensure it’s suitable for your specific needs and trimester.
Do prostaglandin-free serums work on eyebrows?
Yes. Many formulas, such as The Ordinary Multi-Peptide Lash and Brow Serum, are designed to enhance both lashes and brows. With consistent use—typically 4–8 weeks—they can help fill sparse areas, improve density, and create a thicker, fuller appearance. Regular application and patience are key to seeing visible improvements.
Are prostaglandin-free serums suitable for all skin types?
Most of these serums are created to suit a wide range of skin types, from dry to oily or combination. People with sensitive or allergy-prone skin should still choose ophthalmologist-tested, fragrance-free products and perform a patch test first. This helps prevent irritation on the delicate eye area before daily use.
Can I use these serums with eyelash curlers?
Yes, you can safely use an eyelash curler after applying serum, but allow the serum to dry completely first—usually one to two minutes. Using the curler gently prevents lash breakage and ensures the serum remains effective. Avoid tugging or pressing too hard to protect both lashes and follicles.
Do prostaglandin-free serums expire?
Like most cosmetics, these serums have a shelf life. Check the packaging for an expiration date or the “period after opening” (PAO) symbol, which is usually 6–12 months. Store the serum in a cool, dry place and discard it if it changes in colour, smell, or consistency to avoid irritation.
Can men use prostaglandin-free eyelash serums?
Absolutely. These products are unisex and work effectively for anyone seeking longer, fuller lashes or denser brows. Men can follow the same daily application routine recommended on the product label. Consistency is essential—results typically appear within one to two lash cycles, about six to eight weeks.
Are results permanent with prostaglandin-free serums?
No, the results are not permanent. Eyelashes naturally shed and regrow in cycles of roughly six to eight weeks. Once you stop using the serum, new lashes will return to their natural length and thickness. To maintain enhanced length and volume, continued regular application is necessary.
Can I use multiple serums at once?
It’s best to stick to a single prostaglandin-free serum. Combining multiple serums can increase the risk of irritation, allergic reactions, or ingredient conflicts, and it doesn’t speed up growth. For best results, choose one high-quality formula, follow the recommended dosage, and allow time for visible improvements.
How Do Fuller Lash Growth Serums Work on Brow Hairs?
Fuller lash growth serums can also enhance brow hairs by nourishing follicles and extending their growth phase. Prostaglandin-free formulas often use ingredients like green tea extract, rich in antioxidants to protect follicles and reduce breakage, and clover flower extract, which stimulates dormant follicles for improved density.
Sources
- Alvin G, Chernykh V, Chan M. (2020). Peptides: A Novel Approach to Enhance Eyelash and Eyebrow Growth. Journal of Dermatology and Clinical Research. Doi: 10.47739/2373-9371/1137. Read the study
- Sachdev M, Velugotla K, Revanker S, et al. (2020). An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum. J Clin Aesthet Dermatol, 13(2), 61–66. Read the study
- American Academy of Ophthalmology. (2024). How To Use Cosmetics Safely Around Your Eyes. By Dan Gudgel. Reviewed by Rebecca J. Taylor, MD. Edited by Vered Hazanchuk. Read the article
- Jamison A, Okafor L, Ullrich K. (2022). Do Prostaglandin Analogue Lash Lengtheners Cause Eyelid Fat and Volume Loss? Aesthetic Surgery Journal, 42(11), 1241–1249. Read the study
- NHS. (n.d.). Find dermatology services. National Health Service UK. Visit the page
