DHT Blocker Shampoo Side Effects On Male And Female: Full List

Medically reviewedby Dr. Ahmad Chaudhry M.B.B.S.
WrittenbyDr. Edna Skopljak, M.D.
Last updated

Dr. Ahmad Chaudhry M.B.B.S. is a House Physician in the Medical Unit 3 Allied Hospital, Faisalabad, and deals with hepatic, cardiac, neurological, and dermatological issues daily. He did his MBBS from Punjab Medical College, Faisalabad. He believes that a good haircare routine is one where you nourish it naturally. During his free time, he works as a dermatologist for Scandinavian Biolabs. Read more...

DHT blocker shampoo side effects are a crucial consideration for anyone looking to combat hair loss.

While these shampoos are designed to help prevent hair thinning and promote hair growth by blocking dihydrotestosterone (DHT), it's essential to understand the potential downsides.

In this article, we'll delve into the common side effects of DHT blocker shampoos, helping you make an informed decision about their use in your hair care routine.

How does blocking DHT stop hair loss?

Blocking DHT helps stop hair loss by preventing the hormone from binding to androgen receptors in hair follicles, which can cause them to shrink and eventually stop producing hair.

Dihydrotestosterone (DHT) is a male sex hormone essential for male sexual development but becomes less significant after adolescence. However, DHT can negatively impact healthy hair growth.

Excessive DHT in men is a primary cause of male pattern hair loss, or androgenetic alopecia. This hormone binds to androgen receptors in hair follicles around the hairline, crown, and mid-scalp, leading to follicle miniaturization.

This process results in damaged follicles that no longer produce hair, manifesting as receding hairlines, bald spots, or diffuse thinning, particularly in women.

By using DHT blockers, the body converts less testosterone to DHT, reducing its presence and its ability to bind to hair follicle receptors.

Consequently, this helps prevent hair loss and promotes healthier hair growth, particularly in individuals whose follicles are sensitive to DHT.

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What is the ingredient in a DHT blocker shampoo that can cause side effects?

The active ingredient in your DHT shampoo can be the reason behind the side effects.

Ketoconazole

Ketoconazole, or ketoconazole shampoo, is a potent antifungal that targets scalp conditions and reduces DHT levels, potentially leading to irritation or allergic reactions in sensitive individuals.

Saw Palmetto

Derived from the fruit of the saw palmetto tree, this natural DHT blocker is believed to slow hair loss by blocking DHT. Its use can occasionally result in scalp itchiness or irritation.

Tea Tree Oil

Known for its antimicrobial and anti-inflammatory properties, tea tree oil is used to cleanse the scalp and prevent dandruff. However, this natural ingredient may cause allergic reactions or skin irritation in some people.

Pyrithione Zinc

This ingredient is effective against dandruff and seborrheic dermatitis. While beneficial for scalp health, it can sometimes lead to dryness or irritation of the scalp.

Salicylic Acid

Used to remove dead skin cells and excess sebum from the scalp, salicylic acid can promote a healthy hair growth environment. Nonetheless, it might cause skin dryness or irritation in higher concentrations.

Do DHT blocking shampoos have side effects?

DHT blocking shampoos are generally safe for most people, but some users may experience side effects such as itching, redness, a burning sensation on the scalp, dryness, and irritation. Scalp inflammation is also a possibility.

In rare cases, severe allergic reactions like anaphylaxis can occur, requiring urgent medical attention if you experience symptoms such as swelling in the mouth or throat or chest tightness.

Oral DHT blockers like Finasteride have more significant side effects due to their systemic nature, impacting the entire body. These side effects can be more severe compared to those from topical DHT blocking shampoos.

DHT blocker shampoo side effects include:

  • Erectile dysfunction, a potential issue affecting sexual health
  • Gynecomastia and other breast tissue problems, leading to unwanted changes
  • Thicker, darker facial and body hair, resulting in unintended hair growth in other areas
  • Fertility problems, possibly impacting reproductive health
  • Anxiety and depression, leading to mental health concerns
  • Nausea and vomiting, causing gastrointestinal discomfort

How to minimize DHT?

To minimize side effects, it's important to focus on factors that directly impact how these DHT shampoos interact with your scalp health and hair growth cycle.

Here are a few ways you can minimize DHT side effects:

1. Follow Application Guidelines Precisely

Adhere closely to the recommended amount and frequency of use provided by the anti DHT shampoo manufacturer. Using too much shampoo or applying it too frequently can exacerbate side effects.

2. Gradual Introduction to Your Routine

Introduce the DHT blocker shampoo into your hair care routine gradually, starting with fewer applications per week and slowly increasing as your scalp adjusts, to minimize potential irritation or adverse effects.

3. Rinse Thoroughly

Ensure you rinse your hair and scalp thoroughly after each use to remove all traces of the shampoo. Residual products can lead to scalp irritation or dryness.

4. Moisturize and Condition

Use a nourishing conditioner or a scalp moisturizer after shampooing, especially if you experience dryness or irritation from the DHT blocking shampoo. This can help restore moisture balance and soothe the scalp.

5. Monitor Scalp and Hair Health

Regularly assess your scalp for signs of irritation, such as redness, itching, or flaking, and monitor your hair for changes in texture or increased shedding. These observations can help you adjust your use of the product accordingly.

6. Patch Test for Sensitivity

Before fully integrating a DHT blocker shampoo into your regimen, perform a patch test by applying a small amount to a discreet area of your scalp. Wait 24 to 48 hours to observe any adverse reactions.

7. Limit Concurrent Hair Treatments

Avoid using other potentially irritating scalp or hair treatments in conjunction with a DHT blocker shampoo, such as chemical hair dyes, perms, or relaxers, to reduce the overall burden on your scalp.

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What to do if you see side effects?

In case of severe side effects of DHT blockers, consult a doctor as soon as possible. Do not apply the DHT blocking shampoo again and wait for the doctor’s instruction to alleviate the side effects. They will also be able to give you alternative hair loss treatment options depending on your male or female hair loss.

    References

    1. Dihydrotestosterone [Internet]. [cited 2021 Sep 19]. Available from: https://www.yourhormones.info/hormones/dihydrotestosterone/
    2. Burke D. Allergic Reaction: Symptoms, Treatment, Prevention & More [Internet]. 2021 [cited 2021 Sep 19]. Available from: https://www.healthline.com/health/allergies/allergic-reaction
    3. Green B. How Bad are Parabens for Your Hair? [Internet]. 2018 [cited 2021 Sep 19]. Available from: https://voiceofhair.com/how-bad-are-parabens-for-your-hair/
      Dr. Edna Skopljak, M.D.

      About the Writer

      Edna Skopljak, MDUniversity of Ljubljana, Faculty of Medicine

      Edna Skopljak, MD is a clinical doctor at the University Medical Center Ljubljana and a PhD candidate in Biomedicine at the University of Ljubljana. She combines clinical work with research and medical editing, bringing a clear, evidence-based lens to patient education. Previously, she held roles in the pharmaceutical sector (product management and chief medical officer) and served as a medical production editor for the journal Biomolecules and Biomedicine.

      Dr. Skopljak’s publications span clinical topics, including urology and orthopedics. She has co-authored work affiliated with the Department of Orthopedic Surgery at University Medical Centre Ljubljana. She trained in medicine with early clinical experience in Slovenia, reflecting a long-standing focus on practical, patient-facing care.

      She strictly follows our Editorial Standards: All medical statements are grounded in authoritative guidelines, FDA labels, and peer-reviewed studies, with clear distinction between approved treatments and adjunctive options.